EB-42486

CAT: 0804-HY-142647-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-142647-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50: [1][2].
CAS Number
[2390475-81-5]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eb-42486.html
Purity
99.62
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N(C)C2=NN=NN2C1(C)C)NC3=CC4=C(NN=C4C5=CC=CC=C5)C=C3
Molecular Formula
C22H22N8O
Molecular Weight
414.46
Precautions
H228, H315, H319
References & Citations
[1]Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63 (23) :14821-14839. |[2]Thakur G, et al. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes (Basel) . 2022 Aug 11;13 (8) :1426.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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