EB-42486

• Description :

  EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50: [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H228, H315, H319

• Target :

  LRRK2

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/eb-42486.html

• Purity :

  99.62

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C)N(C)C2=NN=NN2C1(C)C)NC3=CC4=C(NN=C4C5=CC=CC=C5)C=C3

• Molecular Formula :

  C22H22N8O

• Molecular Weight :

  414.46

• Precautions :

  H228, H315, H319

• References & Citations :

  [1]Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63 (23) :14821-14839. |[2]Thakur G, et al. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes (Basel) . 2022 Aug 11;13 (8) :1426.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2390475-81-5]