Products for Research Use Only
RegisterLogin

8-Hydroxyguanosine

CAT: 0804-HY-113262-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-113262-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome[1][2][3][4].
CAS Number
3868-31-3
Product Name Alternative
CP 526555-15N,13C,d10, CP 526555 hydrochloride
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Endogenous Metabolite; Interleukin Related
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8-Hydroxyguanosine.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC3=C2N=C(N)NC3=O)=O)O1
Molecular Formula
C10H13N5O6
Molecular Weight
299.24
Precautions
H315, H319, H320
References & Citations
[1]Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49 (20) :5518-22.|[2]Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70 (3) :447-50.|[3]Ahmad A, et al. 8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes. Cell Immunol. 1985 Aug;94 (1) :276-80. |[4]Choi S, et al. Anti-inflammatory effects of 8-hydroxy-2'-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice. Free Radic Biol Med. 2007 Dec 15;43 (12) :1594-603.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Chemical Information

8-Hydroxyguanosine

8-Hydroxyguanosine is a purine nucleoside.

CAS Number3868-31-3
PubChem CID135407175
IUPAC Name2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,7-dihydropurine-6,8-dione
Molecular FormulaC10H13N5O6
Molecular Weight299.24
XLogP-3.6
Topological Polar Surface Area170
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity574
SMILES
C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)NC(=N3)N)NC2=O)O)O)O
InChI
InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1
InChIKey
FPGSEBKFEJEOSA-UMMCILCDSA-N
Chemical Structure
2D Structure
2D structure of 8-Hydroxyguanosine
CAS: 3868-31-3
CID: 135407175
Formula: C10H13N5O6
MW: 299.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight299.24
XLogP3-3.6
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass299.08658315
Monoisotopic Mass299.08658315
Topological Polar Surface Area170 Ų
Heavy Atom Count21
Formal Charge0
Complexity574
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-113338-018-Hydroxyguanine
HY-113338A8-Hydroxyguanine (hydrochloride)
HY-N8842-018,8''-Bibaicalein
HY-160589Nav1.8-IN-8
HY-N136418,8''-Biskoenigine
HY-161737-01YT-8-8
HY-W032015S21-Bromooctane-8,8,8-d3
HY-D0062-01(-) -8,8-Dichlorocampherylsulfonyl-oxaziridine
HY-153543-01TLR7/8 agonist 8
HY-149583Aβ-IN-8

Alternative Products

CatalogName
ALX-480-075-M0058-Hydroxyguanosine
H9076-018-Hydroxyguanosine (8-OHG)
MBS613207-01Hydroxyguanosine 8 (8-OHG)
GWB-713F328-Hydroxyguanosine Antibody
A18658-508-Hydroxyguanosine 50mg
A18658-258-Hydroxyguanosine 25mg
A18658-108-Hydroxyguanosine 10mg
A18658-28-Hydroxyguanosine 2mg
A18658-58-Hydroxyguanosine 5mg

Popular Products