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8-Hydroxyguanine (hydrochloride)

CAT: 0804-HY-113338ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113338ASize:1 Each
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Description
8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage[1][2].
CAS Number
1246818-54-1
Product Name Alternative
8-Oxoguanine (hydrochloride) ; 8-oxo-Gua (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/8-hydroxyguanine-hydrochloride.html
Smiles
O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl
Molecular Formula
C5H6ClN5O2
Molecular Weight
203.59
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374 (2) :233-6.|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel) . 2023 Jun 19;12 (6) :1300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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