8-Hydroxyguanine

• Product Name Alternative:

  2'3'-didehydro-2'3'-dideoxyadenosine

• UNSPSC Description:

  8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/8-Hydroxyguanine.html

• Purity:

  98.37

• Solubility:

  1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 12 with 1M NaOH)|DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : < 1 mg/mL|H2O : 4.72 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)

• Smiles:

  O=C1NC(N)=NC2=C1NC(N2)=O

• Molecular Weight:

  167.13

• References & Citations:

  [1]Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10.|[2]Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50.|[3]Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  5614-64-2