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8-Hydroxyguanine

CAT: 0804-HY-113338-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113338-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].
CAS Number
5614-64-2
Product Name Alternative
8-Oxoguanine; 8-oxo-Gua
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/8-Hydroxyguanine.html
Purity
98.0
Solubility
1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 12 with 1M NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4.72 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)
Smiles
O=C1NC(N)=NC2=C1NC(N2)=O
Molecular Formula
C5H5N5O2
Molecular Weight
167.13
Precautions
H315, H319, H335
References & Citations
[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374 (2) :233-6.|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel) . 2023 Jun 19;12 (6) :1300.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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