8-Hydroxyguanine

• Description :

  8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].

• CAS Number :

  [5614-64-2]

• Product Name Alternative :

  8-Oxoguanine; 8-oxo-Gua

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/8-Hydroxyguanine.html

• Purity :

  98.0

• Solubility :

  1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 12 with 1M NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4.72 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)

• Smiles :

  O=C1NC(N)=NC2=C1NC(N2)=O

• Molecular Formula :

  C5H5N5O2

• Molecular Weight :

  167.13

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374 (2) :233-6.|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel) . 2023 Jun 19;12 (6) :1300.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite