Recombinant Mouse IL-18

• Description :

  Interleukin-18 (IL-18) is a proinflammatory cytokine that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection, and IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders. Mouse IL-18 Recombinant Protein is purified interleukin-18 produced in yeast.

• Synonyms :

  Mouse ; IL-18

• Label :

  ICT

• Type :

  Recombinant Protein

• Source :

  Yeast

• Sequence :

  NFGRLHCTTA VIRNINDQVL FVDKRQPVFE DMTDIDQSAS EPQTRLIIYM YKDSEVRGLA VTLSVKDSKM STLSCKNKII SFEEMDPPEN IDDIQSDLIF FQKRVPGHNK MEFESSLYEG HFLACQKEDD AFKLILKKKD ENGDKSVMFT LTNLHQS (157)

• Assay Protocol :

  The Mouse IL-1 alpha protein can be used in cell culture, as an IL-1 alpha ELISA Standard, and as a Western Blot Control.

• Form :

  Lyophilized

• Shipping Conditions :

  Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping

• Storage Temperature :

  -20°C

• Notes :

  20% discount

• Calculated Molecular Weight :

  18.1 kDa

• Target Description :

  Interleukin-18 (IL-18) is a proinflammatory cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating macrophages or other cells., , Apart from its physiological role, interleukin-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders. This proinflammatory cytokine can induce the IFN-gamma production of T cells, and the combination of this cytokine and IL-12 has been shown to inhibit IL-4 dependent IgE and IgG1 production and to enhance IgG2a production of B cells.