Recombinant Mouse IL-13

CAT: 0436-6553Size: 5 µgDry Ice: NoHazardous: No
CAT#:0436-6553Size:5 µg
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Description
IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.
Synonyms
Mouse ; IL-13
Label
ICT
Type
Recombinant Protein
Source
Yeast
Sequence
GPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F (111)
Assay Protocol
The Mouse B7-H2 protein can be used in cell culture, as a B7-H2 ELISA Standard, and as a Western Blot Control.
Form
Lyophilized
Shipping Conditions
Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping
Storage Temperature
-20°C
Notes
20% discount
Calculated Molecular Weight
12.2 kDa
Target Description
Interleukin-13 (IL-13) is secreted by many cell types, but especially T helper type 2 (Th2) cells. IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues., , The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. Thus, although IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells, deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. In comparison, deletion of IL-4 abrogates these responses. Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.

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