[KO Validated] STAT5B polyclonal antibody

CAT: 0384-BS78225-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS78225-01Size:50 µL
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Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
STAT5B; STAT5; signal transducer and activator of transcription 5B
Swiss Prot
P51692
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human STAT5B (NP_036580.2) .
Conjugation
Unconjugated
Applications
WB, IHC, IP, IF/ICC
Dilution
WB,1:500 - 1:2000|IHC,1:50 - 1:100|IP,1:50 - 1:200|IF/ICC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
92KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Host or Source
Rabbit

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