[KO Validated] STAT5B Rabbit mAb (AMR12752N)

CAT: 0882-AMR12752N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-AMR12752N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] STAT5B Rabbit mAb (AMR12752N) .

Synonyms

STAT5; STAT5B

Gene ID

6777

UniProt

P51692

Cellular Locus

Cytoplasm, Nucleus

Dilution

WB 1:500 - 1:2000 IP 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 90kDa Observed MW: 90KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6777

Uniprot URL

https://www.uniprot.org/uniprot/P51692

AA Sequence

Email for sequence

UniProtKB · P51692

Signal transducer and activator of transcription 5B

STA5B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P51692
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: STAT5B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q8WWS8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantDwarfism

PTM

Phosphoprotein

Domain

SH2 domain

Biological process

TranscriptionTranscription regulation

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