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Antimalarial agent 38

CAT: 0804-HY-157892-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157892-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine -sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model[1].
CAS Number
123580-46-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-38.html
Purity
99.55
Smiles
O=C(COC1=C(OC)C=CC(C(OC2=C3C(O)=CC(OCC(N4CCN(CC4)CC5=CC=C(C(OC)=C5OC)OC)=O)=C2)=CC3=O)=C1)OCC
Molecular Formula
C36H40N2O12
Molecular Weight
692.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Auffret G, et al., Synthesis and antimalarial evaluation of a series of piperazinyl flavones. Bioorg Med Chem Lett. 2007 Feb 15;17 (4) :959-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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