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Ginsenoside Rg5

CAT: 0804-HY-N0908-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0908-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM) . Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.
CAS Number
186763-78-0
UNSPSC
12352005
Hazard Statement
H302
Target
COX; IGF-1R; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Ginsenoside-Rg5.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@@H](/C(C)=C/C/C=C(C)\C)CC2)([H])[C@]3(CC[C@@H]4O[C@@](O[C@H](CO)[C@@H](O)[C@@H]5O)([H])[C@@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)C
Molecular Formula
C42H70O12
Molecular Weight
767.00
Precautions
H302
References & Citations
[1]Cho YL, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015 Jan 2;290 (1) :467-77.|[2]Li W, et al. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients. 2016 Sep 13;8 (9) . pii: E566.|[3]Kim SJ, et al. Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5. J Ginseng Res. 2015 Apr;39 (2) :125-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; RelA/p65

Chemical Information

Ginsenoside Rg5

Ginsenoside Rg5 is a triterpenoid saponin. It has a role as a metabolite.

CAS Number186763-78-0
PubChem CID11550001
IUPAC Name(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2E)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Molecular FormulaC42H70O12
Molecular Weight767.0
XLogP5.4
Topological Polar Surface Area199
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count12
Rotatable Bond Count9
Heavy Atom Count54
Formal Charge0
Complexity1380
SMILES
CC(=CC/C=C(\C)/[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)C
InChI
InChI=1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10-11,23-38,43-50H,9,12-20H2,1-8H3/b22-11+/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1
InChIKey
NJUXRKMKOFXMRX-RNCAKNGISA-N
Chemical Structure
2D Structure
2D structure of Ginsenoside Rg5
CAS: 186763-78-0
CID: 11550001
Formula: C42H70O12
MW: 767.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight767.0
XLogP35.4
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count12
Rotatable Bond Count9
Exact Mass766.48672766
Monoisotopic Mass766.48672766
Topological Polar Surface Area199 Ų
Heavy Atom Count54
Formal Charge0
Complexity1380
Isotope Atom Count0
Defined Atom Stereocenter Count19
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-N0598-01Ginsenoside F1
HY-N0043-01Ginsenoside Rd
HY-N12366Ginsenoside Rs1
HY-N6580-01Ginsenoside Rg4
HY-108277-01Ginsenoside F5

Alternative Products

CatalogName
OG31930-01Ginsenoside Rk1 - Ginsenoside Rk1:Ginsenoside Rz1 (5:2)
300355Ginsenoside Rg3 (20 (s) -Ginsenoside Rg3)
300354Ginsenoside Rg2 (20 (s) -Ginsenoside Rg2)
N1613-5.1Ginsenoside Rg1
N1619-20Ginsenoside Rb2
MDA73367-01Ginsenoside RS1
CS-BS-00118Ginsenoside F1
ZKA25028-01Ginsenoside rc
IDA45941-01Ginsenoside Ra1
OG31929-01Ginsenoside Rk2

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