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Ginsenoside Rg4

CAT: 0804-HY-N6580-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-N6580-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ginsenoside Rg4 is an orally active protopanaxatriol type ginsenoside. Ginsenoside Rg4 can activate PI3K, AKT and GSK-3β signaling. Ginsenoside Rg4 can inhibit ROS and inflammatory cytokine levels. Ginsenoside Rg4 can be used for the researches of inflammation, infection and metabolic disease, such as sepsis and lung inflammation[1][2][3].
CAS Number
126223-28-7
UNSPSC
12352005
Target
Akt; GSK-3; Interleukin Related; PI3K; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ginsenoside-rg4.html
Purity
99.94
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
C[C@]12[C@@]3(C)[C@@]([H])([C@H](CC3)/C(C)=C\C/C=C(C)\C)[C@@H](C[C@@]1([C@]4(C)[C@@]([H])([C@H](C2)O[C@]5([C@H](O[C@]6([C@H](O)[C@H](O)[C@H]([C@@H](O6)C)O)[H])[C@@H](O)[C@@H]([C@H](O5)CO)O)[H])C([C@H](CC4)O)(C)C)[H])O
Molecular Formula
C42H70O12
Molecular Weight
767.00
References & Citations
[1]Kim GO, et al. Inhibitory Activities of Rare Ginsenoside Rg4 on Cecal Ligation and Puncture-Induced Sepsis. Int J Mol Sci. 2022 Sep 16;23 (18) :10836.|[2]Lee YH, et al. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway. J Microbiol Biotechnol. 2021 Jul 28;31 (7) :933-941.|[3]Wonhwa Lee, et al. Pulmonary Protective Functions of Rare Ginsenoside Rg4 on Particulate Matter-induced Inflammatory Responses. Biotechnology and Bioprocess Engineering 24: 445-453 (2019) .
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GSK-3β; IL-1

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