Ginsenoside Rd

CAT: 0804-HY-N0043-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0043-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
CAS Number
[52705-93-8]
Product Name Alternative
Gypenoside VIII
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; COX; Cytochrome P450; Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Ginsenoside-Rd.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@](CC/C=C(C)/C)([C@]1([H])[C@]([C@H](O)C[C@@]2([H])[C@@]3(C)CC[C@]4([H])[C@]2(C)CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C4(C)C)([H])[C@@]3(C)CC1)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O
Molecular Formula
C48H82O18
Molecular Weight
947.15
Precautions
H302, H315, H319, H335
References & Citations
2+Min/+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; CYP1; CYP2; CYP3; L-type calcium channel; NF-κB

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