Recombinant Cynomolgus TPBG/5T4 (C-6His)

Recombinant Cynomolgus TPBG/5T4 (C-6His)

• Background: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
• Abbreviation: TPBG;5T4
• Synonyms: 5T4 Protein, 5T4AG Protein, Human, M6P1 Protein, WAIF1 Protein
• CAS Number: 9000-83-3
• UniProt: Q4R8Y9
• Accession Number: Q4R8Y9
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-His
• Sequence: Thr35-Ser355
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 55-80 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.