Recombinant Cynomolgus FGL1 (C-6His)

Recombinant Cynomolgus FGL1 (C-6His)

• Background: Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .
• Abbreviation: FGL1
• Synonyms: 425O18-1, Angiopoietin-like protein 4, Angiopoietin-related protein 4, Angptl4, Farp, Fasting-induced adipose factor, Fiaf, HFARP, Hepatic fibrinogen/angiopoietin-related protein, Ng27, Secreted protein Bk89
• CAS Number: 9000-83-3
• UniProt: A0A2K5X990
• Accession Number: A0A2K5X990
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-His
• Sequence: Leu23-Ile312
• Applications: BLI
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Loaded Cynomolgus LAG-3-Fc(Cat#PKSQ050015) on Protein A Biosensor, can bind Cynomolgus FGL1-His(Cat#PKSQ050095) with an affinity constant of 28.6nM as determined in BLI assay.
• Reconstitution: Not Applicable
• Molecular Weight: 35 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.