MITF Polyclonal Antibody

• Background:

  This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

• Abbreviation:

  MITF

• UniProt:

  O75030

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Recombinant fusion protein of human MITF (NP_937801.1) .

• Target:

  MITF; CMM8; COMMAD; MI; WS2; WS2A; bHLHe32

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cancer; Epigenetics and Nuclear Signaling; Immunology

• Purification:

  Affinity purification

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  40kDa/46kDa/52kDa/55kDa/56kDa/57kDa/58kDa

• Observed Molecular Weight:

  65kDa

• Citation 01:

  https://www.sciencedirect.com/science/article/pii/S0923181120302000

• Isotype:

  IgG