PAK1 Antibody Polyclonal Antibody

• Background:

  P21-activated kinase-1 (PAK1) is an enzyme associated with multiple metabolic networks and different types of cancers.PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. The p21 protein (Cdc42/Rac) -activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors. PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small-molecule inhibition.

• Abbreviation:

  PAK1

• UniProt:

  P35465

• Host:

  Rabbit

• Reactivity:

  Rat

• Immunogen:

  A synthetic peptide corresponding to the C-terminus of the Rat PAK1

• Target:

  PAK; Pak1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; ICC/IF; IP

• Purification:

  Protein A & Antigen Affinity

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000; ICC/IF 1:1500-1:50000; IP 0.2-1 μL/mg of lysate

• Buffer:

  0.2 μm filtered solution in PBS

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  66 kDa

• Observed Molecular Weight:

  72 kDa

• Isotype:

  IgG