Recombinant MiTF Monoclonal Antibody

• Background:

  This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

• Abbreviation:

  MITF

• UniProt:

  O75030

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human MiTF protein

• Target:

  CMM; bHLHe; MITF; CMM8; COMMAD; MI; WS2; WS2A; bHLHe32

• Clonality:

  Monoclonal, Recombinant

• Clone:

  2C7

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Epigenetics and Nuclear Signaling; Immunology

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  IHC 1:200-500; WB 1:1000-5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  58 kDa

• Observed Molecular Weight:

  58 kDa

• Isotype:

  IgG, κ