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MITF Polyclonal Antibody

CAT: 0763-E-AB-60287-02Size: 120 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-60287-02Size:120 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Abbreviation
MITF
UniProt
O75030
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant fusion protein of human MITF (NP_937801.1) .
Target
MITF; CMM8; COMMAD; MI; WS2; WS2A; bHLHe32
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Immunology
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
40kDa/46kDa/52kDa/55kDa/56kDa/57kDa/58kDa
Observed Molecular Weight
65kDa
Citation 01
https://www.sciencedirect.com/science/article/pii/S0923181120302000
Isotype
IgG

UniProtKB · O75030

Microphthalmia-associated transcription factor

MITF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75030
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MITF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DJL2, D3K197, E9PFN0, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Disease

AlbinismDeafnessDisease variantMicrophthalmiaOsteopetrosisWaardenburg syndrome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmLysosomeMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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