LSM10 Polyclonal Antibody

CAT: 0763-E-AB-18768-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-18768-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

LSm10 (U7 snRNA-associated Sm-like protein LSm10) is a nuclear protein that belongs to the snRNP (small nuclear ribonucleoproteins) Sm protein family. The survival of motor neurons (SMN) complex mediates the assembly of snRNPs involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. LSm10 and LSm11, mammalian homologs of the yeast Sm proteins D1 and D2, are important for U7 snRNP function and subcellular localization. U7 snRNP is an RNA molecule involved in the splicing of animal histone pre-mRNAs. Lsm10 and Lsm11 also associate with pICln (Chloride ion current inducer protein), which interacts with Sm proteins to inhibit their assembly on U RNA. LSm10 interactions with U7 snRNA and pICln may provide the means for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, potentially leading to advances in antisense gene therapy.

Abbreviation

LSM10

UniProt

Q969L4

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Fusion protein of human LSM10

Target

LSM 10; LSM10 U7 small nuclear RNA associated; MGC15749; MST074; MSTP074; U7 snRNA associated Sm like protein LSm10; U7 snRNP specific Sm like protein LSM10

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Epigenetics and Nuclear Signaling

Purification

Antigen affinity purification

Concentration

0.9 mg/mL

Dilution

IHC 1:50-1:300

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · Q969L4

U7 snRNA-associated Sm-like protein LSm10

LSM10_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q969L4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: LSM10
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

mRNA processingmRNA splicing

Cellular component

Nucleus

Molecular function

RibonucleoproteinRNA-binding

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Alternative Products

Catalog	Name
MBS2562584-01	LSM10 Polyclonal Antibody
JOT-AP11157-01	LSM10 Rabbit Polyclonal Antibody
NBP3-04424-100ul	Rabbit Polyclonal LSM10 Antibody
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