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Elabela (19-32)

CAT: 0804-HY-P2106-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2106-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Elabela (19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela (19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela (19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
CAS Number
1886973-05-2
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; Arrestin
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/elabela-19-32.html
Purity
99.64
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CCC(N1)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O
Molecular Formula
C75H119N25O17S2
Molecular Weight
1707.03
References & Citations
[1]Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59 (7) :2962-72.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Cell Stress Chaperones. 2023 Jan;28 (1) :91-103.|J Cardiovasc Transl Res. 2022 Jun;15 (3) :535-547.|Mol Med. 2024 Nov 20;30 (1) :223.|Free Radic Biol Med. 2022 Mar:181:130-142.|Nat Commun. 2025 Jul 21;16 (1) :6682.

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