KU-32

• Description :

  KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/KU-32.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(O2)C(C=C(NC(C)=O)C2=O)=CC=C1O[C@H]3[C@@H]([C@@H]([C@@H](OC)C(C)(C)O3)O)O

• Molecular Formula :

  C20H25NO8

• Molecular Weight :

  407.41

• References & Citations :

  [1]Farmer K, et al. KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Exp Diabetes Res. 2012;2012:671673.|[2]Urban MJ, et al. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN Neuro. 2010 Aug 11;2 (4) :e00040.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [956498-70-7]