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ACH-000143

CAT: 0804-HY-138626-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138626-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].
CAS Number
2225836-30-4
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ach-000143.html
Concentration
10mM
Purity
98.58
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O
Molecular Formula
C13H16ClN3O3
Molecular Weight
297.74
References & Citations
[1]Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64 (4) :1904-1929.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1; MT2

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