LCRF-0004

CAT: 0804-HY-123225Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-123225Size:1 Each

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Description

LCRF-0004 is a potent inhibitor of RON kinase, with the IC50 value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC50 value of 12 nM. LCRF-0004 plays an important role in cancer research[1].

CAS Number

1229611-73-7

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lcrf-0004.html

Smiles

O=C(NC1=CC=C(C(F)=C1)OC2=C3C(C=C(S3)C4=CN(C=N4)C)=NC=C2)C5=C(N(N=C5)C6=CC=CC=C6)C(F)(F)F

Molecular Formula

C28H18F4N6O2S

Molecular Weight

578.54

References & Citations

[1]Stéphane L Raeppel, et al. Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2015 Jun 15;25 (12) :2527-31.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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LCRF-0004

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