Products for Research Use Only
RegisterLogin

S18-000003

CAT: 0804-HY-119366-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119366-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 50>10 μM) . S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations[1][2].
CAS Number
2068119-11-7
Product Name Alternative
Stibogluconate (trisodium nonahydrate)
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s18-000003.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(NC(C(C)(C)C2=CC=C(NC(CC3=CC=C(S(CC)(=O)=O)C=C3)=O)C=C2F)=O)C=CC(F)=C1
Molecular Formula
C26H25F3N2O4S
Molecular Weight
518.55
References & Citations
[1]Sasaki Y, et, al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28 (22) :3549-3553.|[2]Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93 (3) :176-185.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

Related Products

CatalogName
HY-169210ECDD-S18
HY-138626-01ACH-000143
HY-153019-01NUCC-0000323
HY-151500CJBSNF-000028
HY-112584-01JBSNF-000088
HY-161762-01RA-0002034
HY-151500A-01JBSNF-000028 (TFA)
HY-151500B-01JBSNF-000028 (hydrochloride)
HY-151611UAMC-00050
HY-161762A(E/Z) -RA-0002034

Alternative Products

CatalogName
BA8322-1S18-000003
A19105-25S18-000003 25mg
A19105-500S18-000003 500mg
A19105-10S18-000003 10mg
A19105-5S18-000003 5mg
A19105-1S18-000003 1mg
A19105-100S18-000003 100mg
A19105-50S18-000003 50mg
A19105-10mM-DS18-000003 10mM * 1mL in DMSO

Popular Products