TTK/PLK1-IN-1

• UNSPSC Description:

  TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC50 of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC[1].

• Target Antigen:

  Mps1; Polo-like Kinase (PLK)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ttk-plk1-in-1.html

• Smiles:

  O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCNCC5)C=C4OC)N=C3N2C=C1)NC6=C(C)C=CC=C6C

• Molecular Weight:

  523.63

• References & Citations:

  [1]Lane H, et al., Pharmaceutical combinations for use in the treatment of neoplastic diseases. WO2023167549.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1817791-70-0