COX-2-IN-6

COX-2-IN-6

• CAS Number: 2756347-91-6
• UNSPSC Description: COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM[1].
• Target Antigen: COX
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cox-2-in-6.html
• Purity: 98.80
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CCCOC1=NC(OCC(C)(O)C)=C(C=C1CO)C2=CC=C(C=C2)S(C)(=O)=O
• Molecular Weight: 409.50
• References & Citations: [1]Zhang Z, et al. Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer. J Med Chem. 2021 Aug 12;64(15):11570-11596.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported