Products for Research Use Only
RegisterLogin

Monomethyl auristatin E intermediate-7

CAT: 0804-HY-78901-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-78901-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E. Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
CAS Number
135383-55-0
UNSPSC
12352005
Hazard Statement
H301
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-7.html
Purity
99.54
Solubility
10 mM in DMSO
Smiles
CC[C@H](C)[C@@H]([C@@H](CC(OC(C)(C)C)=O)O)NC(OCC1=CC=CC=C1)=O
Molecular Formula
C20H31NO5
Molecular Weight
365.46
Precautions
H301
References & Citations
[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(3R,4S,5S)-tert-butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
CAS Number135383-55-0
PubChem CID15736114
IUPAC Nametert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate
Molecular FormulaC20H31NO5
Molecular Weight365.5
XLogP3.4
Topological Polar Surface Area84.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count26
Formal Charge0
Complexity440
SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)O)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C20H31NO5/c1-6-14(2)18(16(22)12-17(23)26-20(3,4)5)21-19(24)25-13-15-10-8-7-9-11-15/h7-11,14,16,18,22H,6,12-13H2,1-5H3,(H,21,24)/t14-,16+,18-/m0/s1
InChIKey
AZTSBAWJROLRIQ-LESCRADOSA-N
Chemical Structure
2D Structure
2D structure of (3R,4S,5S)-tert-butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
CAS: 135383-55-0
CID: 15736114
Formula: C20H31NO5
MW: 365.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.5
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass365.22022309
Monoisotopic Mass365.22022309
Topological Polar Surface Area84.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity440
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-79196-01Monomethyl auristatin E intermediate-15
HY-78899Monomethyl auristatin E intermediate-6
HY-78903-01Monomethyl auristatin E intermediate-9
HY-78910Monomethyl auristatin E intermediate-12
HY-78901AMonomethyl auristatin E intermediate-8
HY-78913-01Monomethyl auristatin E intermediate-14
HY-79205Monomethyl auristatin E intermediate-17
HY-43147Monomethyl auristatin E intermediate-4
HY-33048-01Monomethyl auristatin E intermediate-1
HY-78908-01Monomethyl auristatin E intermediate-11

Alternative Products

CatalogName
OR1032361-01Monomethyl auristatin E intermediate-7
OR1005449Monomethyl auristatin E intermediate-14
OR1036620Monomethyl auristatin E intermediate-9
OR1036317-01Monomethyl auristatin E intermediate-1
T208361-01Monomethyl auristatin E intermediate-8
OR1005081Monomethyl auristatin E intermediate-11
OR1031759Monomethyl auristatin E intermediate-3
OR1006028Monomethyl auristatin E intermediate-2
GTR19261400-01Monomethyl auristatin E intermediate-10
T208363-01Monomethyl auristatin E intermediate-17

Popular Products