RegisterLogin

3MB-PP1

CAT: 0804-HY-102069-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-102069-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8) . 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM) . 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].
CAS Number
[956025-83-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
CDK; DAPK; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/3mb-pp1.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(C)=C3)=NC=N1
Molecular Formula
C17H21N5
Molecular Weight
295.38
Precautions
H302, H315, H319
References & Citations
[1]Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7 (6) :978-81.|[2]Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18 (1) :e1009622. Published 2022 Jan 4.|[3]Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86 (11) :1211-1217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-149710POP-3MB
HY-13804-01PP1
HY-115741-013BrB-PP1
HY-151374-013-IN-PP1
HY-172708ADSPE-PEG3400-PP1
HY-172709DSPE-PEG5000-PP1
HY-172707DSPE-PEG1000-PP1
HY-172708DSPE-PEG2000-PP1
HY-13941-011-Naphthyl PP1
HY-13942-011-NM-PP1

Alternative Products

CatalogName
BUP13472-013MB-PP1
T87237-01POP-3MB
MBS808169-01PP1

Popular Products