3-IN-PP1

• Description:

  3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer[1].

• UNSPSC:

  12352005

• Target:

  PKD

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-in-pp1.html

• Purity:

  99.37

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=C2C (N (C (C) (C) C) N=C2C3=CNC4=C3C=CC=C4) =NC=N1

• Molecular Formula:

  C17H18N6

• Molecular Weight:

  306.37

• References & Citations:

  [1]Philippe Gilles, et al. Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors. Eur J Med Chem

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PKD1; PKD2; PKD3

• CAS Number:

  2227110-54-3