POP-3MB

CAT: 0804-HY-149710Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149710Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM) . POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation[1].
CAS Number
[1144114-27-1]
UNSPSC
12352005
Target
ERK; ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pop-3mb.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSC/C=C(C/C=C(C)/C)/CCC1=CC=C(C2=CC=CC=C2)C=C1)C(O)=O)C(C=CC=C3)=C3OC4=CC=CC=C4
Molecular Formula
C38H39NO4S
Molecular Weight
605.79
References & Citations
[1]Majmudar JD et al. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 1;20 (1) :283-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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