PP1

• Description :

  PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively.

• CAS Number :

  [172889-26-8]

• Product Name Alternative :

  AGL 1872; EI 275

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Apoptosis; Src

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PP1.html

• Purity :

  99.57

• Solubility :

  DMSO : 28 mg/mL (ultrasonic)

• Smiles :

  NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1

• Molecular Formula :

  C16H19N5

• Molecular Weight :

  281.36

• Precautions :

  H301

• References & Citations :

  [1]Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 1996 Jan 12;271 (2) :695-701.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported