3BrB-PP1

• Description :

  3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket) [1][2].

• Product Name Alternative :

  (Rac)-Rebemadlin, PF-2545920 (succinate)

• UNSPSC :

  12352005

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/3brb-pp1.html

• Purity :

  99.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(Br)=C3)=NC=N1

• Molecular Formula :

  C16H18BrN5

• Molecular Weight :

  360.25

• References & Citations :

  [1]Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26 (6) :1654-1667.e7.|[2]Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26 (21) :2921-2928.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [956025-99-3]