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CMS-121

CAT: 0804-HY-135981-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135981-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
CAS Number
1353224-53-9
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cms-121.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O
Molecular Formula
C20H19NO3
Molecular Weight
321.37
References & Citations
[1]Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866.|[2]Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55 (1) :378-89.|[3]Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5 (7) :503-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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