SKA-121

• Description:

  SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/SKA-121.html

• Purity:

  99.69

• Solubility:

  DMSO : ≥ 42.86 mg/mL

• Smiles:

  NC1=NC2=CC (C) =C3C=CC=CC3=C2O1

• Molecular Formula:

  C12H10N2O

• Molecular Weight:

  198.22

• References & Citations:

  [1]Coleman N, et al. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol. 2014 Sep;86 (3) :342-57.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1820708-73-3