ELQ-121

• Description:

  ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO) -site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research[1][2][3].

• UNSPSC:

  12352005

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  FC1=C2C(NC(C)=C(CCCCCCC)C2=O)=CC(F)=C1

• Molecular Formula:

  C17H21F2NO

• Molecular Weight:

  293.35

• References & Citations:

  [1]Probst, A. S., et al., (2025) . In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. Advance online publication. |[2]Eberhard, N., et al., (2020) . Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, 96.|[3]Winter, R., et al., (2011) . Optimization of endochin-like quinolones for antimalarial activity. Experimental parasitology, 127 (2), 545–551.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1228283-36-0]