PROTAC BRD4 Degrader-24

PROTAC BRD4 Degrader-24

• CAS Number: 2417370-39-7
• UNSPSC Description: PROTAC BRD4 Degrader-24 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker[1].
• Target Antigen: PROTAC-Linker Conjugates for PAC
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-brd4-degrader-for-pac-1.html
• Purity: 99.61
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O)=O
• Molecular Weight: 1306.58
• References & Citations: [1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported