PROTAC BRD4 Degrader-24

• UNSPSC Description:

  PROTAC BRD4 Degrader-24 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker[1].

• Target Antigen:

  PROTAC-Linker Conjugates for PAC

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-brd4-degrader-for-pac-1.html

• Purity:

  99.61

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O)=O

• Molecular Weight:

  1306.58

• References & Citations:

  [1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2417370-39-7