LTβR-IN-1

LTβR-IN-1

• CAS Number: 2189366-77-4
• UNSPSC Description: LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner[1].
• Target Antigen: NF-κB
• Type: Reference compound
• Related Pathways: NF-κB
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/lt-beta-r-in-1.html
• Purity: 99.92
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: C[C@@H](N(CC1=C2C=CC=C1)C2=O)C(NC3=NC4=CC=CC=C4N3)=O
• Molecular Weight: 320.35
• References & Citations: [1]Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541).
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported