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LTβR-IN-1

CAT: 0804-HY-123984-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123984-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LTβR-IN-1 (Compound 919278) is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner[1].
CAS Number
2189366-77-4
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lt-beta-r-in-1.html
Purity
99.92
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@H](N(CC1=C2C=CC=C1)C2=O)C(NC3=NC4=CC=CC=C4N3)=O
Molecular Formula
C18H16N4O2
Molecular Weight
320.35
Precautions
H315, H319, H320
References & Citations
[1]Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11 (541) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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