LT-188A

• Description:

  LT-188A is a potent TGR5 agonist with an EC50 of 23 μM. LT-188A decreases the levels of inflammatory mediators in macrophages[1].

• UNSPSC:

  12352005

• Target:

  G protein-coupled Bile Acid Receptor 1

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Smiles:

  COC1=C(OC)C=C(C[C@H]2CO[C@H](C3=CC(OC)=C(OC)C=C3)[C@H]2CCOC(/C(C)=C\C)=O)C=C1

• Molecular Formula:

  C28H36O7

• Molecular Weight:

  484.58

• References & Citations:

  [1]Perhal AF, et al. dentification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist. J Nat Prod. 2025 Apr 25;88 (4) :985-995.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2922530-99-0