LT-104A

• Description :

  LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM) . LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2) . LT-104A can be used for inflammation-related disease research[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5

• Molecular Formula :

  C33H34O7

• Molecular Weight :

  542.62

• References & Citations :

  [1]Coffey C, et al. Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans. Eur J Med Chem. 2026;302 (Pt 1) :118285. doi:10.1016/j.ejmech.2025.118285

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE4

• CAS Number :

  [2574572-03-3]