LT-540-717

• Description :

  LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V) . LT-540-717 has potential to be an anti-AML agent[1].

• UNSPSC :

  12352005

• Target :

  FLT3

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lt-540-717.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C(N2CCNCC2)C=C1)C3=NNC=C3NC4=NC=NC(OC5=CC=CC=C5)=C4

• Molecular Formula :

  C24H24N8O2

• Molecular Weight :

  456.50

• References & Citations :

  [1]Zhi Y, et al. Rational design of 4- ((6-phenoxypyrimidin-4-yl) amino) -N- (4- (piperazin-1-yl) phenyl) -1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2143089-35-2]