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(R) -AS-1

CAT: 0804-HY-168773-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168773-01Size:1 mg
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Description
(R) -AS-1 is a selective positive allosteric modulator of the excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. (R) -AS-1 (at doses of 60 and 90 mg/kg) increases spontaneous locomotor activity in mice. Additionally, it demonstrates anticonvulsant activity in mouse models of seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electrical stimuli (32 or 44 mA), with ED50s of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. (R) -AS-1 can be used in neurological disease research[1].
CAS Number
2506367-95-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
EAAT
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Purity
99.90
Smiles
O=C(NCC1=CC=CC=C1)[C@H](N2C(CCC2=O)=O)C
Molecular Formula
C14H16N2O3
Molecular Weight
260.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Abram M, et al. Discovery of (R) -N-Benzyl-2- (2,5-dioxopyrrolidin-1-yl) propanamide [ (R) -AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo. J Med Chem. 2022 Sep 8;65 (17) :11703-11725.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EAAT2

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