MD-265

CAT: 0804-HY-169327-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-169327-01Size:1 mg
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Description
MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754) ; Black: linker; Blue: Lenalidomide (HY-A0003) [1].
CAS Number
[2415160-21-1]
UNSPSC
12352005
Target
MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/md-265.html
Smiles
O=C([C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O)N7CCC(C#CC8=C(C(C9=O)=CC=C8)CN9C(C(N%10)=O)CCC%10=O)CC7
Molecular Formula
C50H51Cl2FN6O6
Molecular Weight
921.88
References & Citations
[1]Aguilar A, et al. Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia. J Med Chem. 2024 Nov 14;67 (21) :19503-19518.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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