MD-224

CAT: 0804-HY-114312-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114312-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent[1]. MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2136247-12-4]
Product Name Alternative
trans-1-Aminocyclobutane-1,3-dicarboxylic acid, R80130, (S)-4-Carboxyphenylglycine, cis-1-Aminocyclobutane-1,3-dicarboxylic acid
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
E1/E2/E3 Enzyme; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/md-224.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O
Molecular Formula
C48H43Cl2FN6O6
Molecular Weight
889.80
Precautions
H315, H319, H320
References & Citations
[1]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62 (2) :448-466
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2

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Alternative Products

CatalogName
MBS3611907-01MD-224
A18712-1MD-224 1mg
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A18712-5MD-224 5mg
A18712-100MD-224 100mg
A18712-200MD-224 200mg
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