FTR-1335

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains) . They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteristic of these drugs.

• Smiles:

  N(C(=O)C1CCCC1)C=2SC=3C(N2)=CC=C(NC(=O)[C@H]4C[C@@H](NCC5=CC6=C(C=C5)C=CC=C6)CCC4)C3

• Molecular Formula:

  C31H34N4O2S

• Molecular Weight:

  526.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  851075-79-1