CB2R agonist 4

• Description :

  CB2R agonist 4 is a cannabinoid receptor 2 (CB2R) agonist with an EC50 value of 6.9 μM. CB2R agonist 4 can induce cell apoptosis, ROS production and protein misfolding. CB2R agonist 4 shows cytotoxicity to a panel of tumor cell lines. CB2R agonist 4 can be used for the research of cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Cannabinoid Receptor; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(OCC1=CC=CC=C1)[C@@H](N2C(C3=CC=CC=C3NC2=O)=O)CC(C)C

• Molecular Formula :

  C21H22N2O4

• Molecular Weight :

  366.41

• References & Citations :

  [1]Ciaglia T, et al. Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution. J Med Chem. 2025 Aug 14;68 (15) :16483-16517.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CB2

• CAS Number :

  [182496-82-8]