Methylene Violet 3RAX

CAT: 0804-HY-W130236-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W130236-01Size:500 mg
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Description
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) [1][2].
CAS Number
[4569-86-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/methylene-violet-3rax.html
Purity
95.54
Solubility
10 mM in DMSO
Smiles
[Cl-].N=1C=2C=CC(N)=CC2[N+](C=3C=CC=CC3)=C4C=C(C=CC14)N(CC)CC
Molecular Formula
C22H23ClN4
Molecular Weight
378.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013.|[2]Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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