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α, β-Methylene-ATP (dilithium)

CAT: 0804-HY-134440Size: 1 EachDry Ice: NoHazardous: No
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Description
α, β-Methylene-ATP dilithium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α, β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC) ; this effect can be blocked by the P2X antagonist PPADS. α, β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α, β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system[1][2][3].
CAS Number
104809-20-3
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/α-β-methylene-atp-dilithium.html
Solubility
10 mM in DMSO
Smiles
OP(OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)(O)=O)(O)=O.[Li].[Li]
Molecular Formula
C11H18Li2N5O12P3
Molecular Weight
519.09
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20 (1) .|[2]Hanna RL, et al. alpha, beta-Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats. J Appl Physiol (1985) . 2002 Sep;93 (3) :834-41.|[3]Fukui M, et al. Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by alpha, beta-methylene-ATP in rats. J Pharmacol Sci. 2004 Feb;94 (2) :153-60
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X1 Receptor; P2X3 Receptor; P2X7 Receptor

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