α,β-Methylene-ATP

CAT:

804-HY-134440A

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CAS Number: 7292-42-4
UNSPSC Description: α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].
Target Antigen: P2X Receptor
Type: Reference compound
Related Pathways: Membrane Transporter/Ion Channel
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/α-β-methylene-atp.html
Solubility: 10 mM in DMSO
Smiles: OP(OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)(O)=O)(O)=O
Molecular Weight: 505.21
References & Citations: [1]Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).|[2]Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-134440A	α,β-Methylene-ATP
HY-108652-02	α,β-Methylene-ATP (trisodium)
HY-134440-01	α,β-Methylene-ATP (dilithium)
HY-108652-03	α,β-Methylene-ATP (trisodium)
HY-134440-03	α,β-Methylene-ATP (dilithium)
HY-134440-02	α,β-Methylene-ATP (dilithium)
HY-108652-01	α,β-Methylene-ATP (trisodium)
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