NRX-252114 B

• Description:

  NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  510.32

• Molecular Formula:

  C22H12Cl2F3N3O2S

• Notes:

  Research use only, not for human use.

• Receptor:

  Wnt/beta-catenin

• CAS Number:

  2763260-39-3